Dr. James A. Grifo and his team at NYU Langone Fertility Center and NYU Grossman School of Medicine launches largest egg freeze study to date
HOUSTON, 28 June 2022 / PRNewswire / – NYU Langone Fertility Center, a member of Inception Fertility’s network of clinical practices, in collaboration with NYU Grossman School of Medicine, has released the largest U.S. report of elective fertility preservation outcomes to date. Inception is the largest provider of comprehensive fertility services in North America. The results of this research were recently published in Fertility and Sterility.
Led by James A. GrifoMD, Ph.D. eggs at a later date – had a baby.
These new findings are based on 15 years of thawing results for frozen eggs for women who delayed pregnancy and faced natural, age-related declines in fertility.. Based on actual clinical experience, the study also reports that 211 infants were delivered from egg freezing and found that a significant number of the women studied had more than one child through egg preservation.
“The results of this groundbreaking study further reinforce that fertility preservation is a viable option for women who want to take control of their fertility and expand their options, empowering them to make reproductive choices that are best for them,” said Dr. Grifo said. “As more women need or need to delay childbirth, egg freezing allows them to serve as their own egg donor, giving them significantly higher chances of success.”
“Inception Fertility congratulates Dr. Grifo and his colleagues at NYU Langone Fertility Center and NYU Grossman School of Medicine on this unprecedented study and that they have moved the fertility industry forward by confirming that women have viable choices regarding their reproductive health,” he said. TJ said. Farnsworth, founder and CEO of Inception Fertility. “We are proud to have NYU Langone Fertility Center as part of our clinical network and look forward to future contributions from this outstanding team.”
Specialists within the NYU Langone Fertility Center were innovators in the development of egg-freezing technology, with the first baby born by egg-freezing at NYU Langone July 2005. NYU Langone Fertility Center joined Inception’s network of clinics in 2018. The center has nearly tripled the number of women starting egg-freezing cycles in 2022 compared to 2019.
“As part of Inception’s clinical network, we are excited to share these findings with our patients as we advise them on their fertility preservation options,” said Dr. Christine Mansfield, Reproductive Specialist and Medical Director at Aspire Fertility Austin and Aspire Fertility Dallas, clinics that are part of Inception’s clinical network. “We congratulate our colleague, Dr. Grifo, and his entire team who successfully presented this study.”
Study details
Within the study, 543 patients participated with a mean age of 38 years at the time of the first egg freeze, which is older than the optimal age for freezing eggs (35 years old or younger). Between 2005 and 2020, these patients underwent 800 egg-freezing cycles, 605 egg thaws, and 436 embryo transfers.
The study found that in general, 39 percent of women between 27-44 years old, with a majority between 35-40 years old at egg freezing, had at least one child of their frozen eggs, which is comparable to age- corresponding IVF outcomes. Over all ages, women who thawed more than 20 adult eggs had a living birth rate of 58 percent, which was profound and unexpected, as this group included patients who were past their reproductive state. In fact, 14 patients who froze eggs at the age of 41–43 years successfully had children from their frozen eggs. As noted, women under the age of 38 who had thawed 20 or more adult eggs achieved a 70 percent live birth rate per patient. The length of frozen egg storage did not change the success rate.
Results also showed that pre-implantation genetic screening with embryos of frozen and eventually thawed eggs resulted in lower miscarriage rates and higher live birth rates per transmission. Such screening also allows for single-embryo transfers, yielding single-ton pregnancies that are safer for both mother and child, the authors say.
Dr Grifo, also a professor in the Department of Obstetrics and Gynecology at NYU Langone, warns that the study is limited by the number of patients. Future larger studies are underway to expand the data set from which patients can benefit and model their expected success rates. He adds that additional studies of a variety of geographic locations and center types are also needed.
Funding support for the fundamental scientific studies that led to NYU Langone’s clinically successful oocyte cryopreservation program was provided by the Carolyn and Malcom Wiener Foundation.
In addition to Dr. Cascante and Dr. Grifo, were other clinical scientists in the study Jennifer K. Blakemoremanaging director; Shannon M. DeVoremanaging director; Brooke Hodes-WertzMD, MPH; Elizabeth Finomanaging director; Alan S. Berkeley, managing director; Carlos M. Parra, MD; and Caroline McCaffrey, PhD. The entire team of embryologists, physicians, nurses, and support staff at the NYU Langone Fertility Center contributed to the success of this study.
Data tov NYU’s procedures and success rates can be found at: https://www.sartcorsonline.com by searching under clinic ID 1895. A comparison of clinic success rates may not make sense because patient medical characteristics, treatment approaches and access criteria for ART may differ from clinic to clinic.
About initial fertility
Beginning Fertility™ (Inception) is a family of fertility brands committed to helping patients build their own families. Built by patients for patients, Inception’s goal is to achieve the highest standard in experience, science, and medicine in an effort to enhance each patient’s experience and achieve better outcomes.
Inception’s medical experts are leading pioneers in fertility care. Our doctors are among the first to use breakthrough-assisted reproductive technologies (ART) – including in vitro fertilization (IVF), pregenetic implant testing (PGT) and fertility conservation services – and they continue to lead the industry by building on these technologies through development, research and thought leadership.
Its growing family of national organizations is an ecosystem of care, affecting every part of the fertility journey, including diagnostics and treatment to financial accessibility. Through this unique ecosystem, Inception is working to fulfill its promise to push the envelope of what is possible to exceed patient expectations.
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